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Figure 2 | BMC Neuroscience

Figure 2

From: Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

Figure 2

Effect of various concentrations of calpain inhibitors, ALLN and PD150606, on glutamate-induced cell death in HT22 cells. HT22 cells were treated with 8 mM glutamate in the presence or absence of 1–50 μM ALLN (A) and 1–100 μM PD150606 (B). Cell death was assessed by measuring LDH release after 8 hrs of treatment *P < 0.05 compared to control; † P < 0.05 compared to glutamate alone.

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BMC Neuroscience

ISSN: 1471-2202

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