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- Open Access
Simulation of AMPA and NMDA contribution to postsynaptic response
© Galindo et al. 2015
- Published: 18 December 2015
- NMDA Receptor
- AMPA Receptor
- Neuronal Plasticity
- Postsynaptic Membrane
- Short Timescale
Other simulations for different trains of neurotransmitter were performed, and similar results were obtained. We also performed simulations for different stimulation frequencies in larger timescales and again, AMPA receptors followed rapid neurotransmitter dynamics while NMDA receptors exhibited changes only in time activation. Then, we conclude that the contribution of AMPA receptors is the most important one in short timescales, whereas NMDA receptors participate mainly in larger timescale responses. These results are the basis of our current work on proposing a postsynaptic model intended to work with our presynaptic model .
C.M.G. thanks CONACYT for the financial support through his graduate scholarship to carry out this investigation.
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