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- Open Access
Mechanisms of cortical high-gamma activity (60-200 Hz) investigated with computational modeling
© Suffczynski et al. 2015
- Published: 4 December 2015
- Somatosensory Cortex
- Cortical Activation
- Principal Cell
- Neural Population
- Cortical Circuit
The HGA appear to be mediated mostly by an excited population of inhibitory fast-spiking interneurons firing at high-gamma frequencies and pacing excitatory regular-spiking pyramidal cells, which fire at lower rates but in phase with the population rhythm. HGA reflects local cortical activation under normal conditions and as such is a good candidate for mapping cortical areas engaged by a specific task. The mechanisms of HGA, in this model of local cortical circuits, appear to be similar to those proposed for hippocampal ripples generated by subset of interneurons that regulate discharge of principal cells.
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