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Hybrid scheme for modeling local field potentials from point-neuron networks

Measurement of the local field potential (LFP) has become routine for assessment of neuronal activity in neuroscientific and clinical applications, but its interpretation remains nontrivial. Understanding the LFP requires accounting for both anatomical and electrophysiological features of neurons near the recording electrode as well as the entire large-scale neuronal circuitry generating synaptic input to these cells. The direct simulation of LFPs in biophysically detailed network models is computationally daunting. Here, we instead propose a hybrid modeling scheme combining the efficiency of simplified point-neuron network models (Fig. 1A) with the biophysical principles underlying LFP generation by multicompartment neurons [1] (Fig 1C). We apply this scheme to a model representing a full-scale cortical network under about 1 square millimeter surface of cat primary visual cortex [2] (Fig. 1A,B) with layer-specific connectivity [3] to predict laminar LFPs (Fig. 1D) for different network states, assess the relative contribution of local neuron populations to the LFP, investigate the role of input correlations and neuron density, and validate linear LFP predictions based on population firing rates. The hybrid scheme is accompanied by our open-source software, hybridLFPy (http://github.com/espenhgn/hybridLFPy).

Figure 1
figure1

Overview of the hybrid scheme for modeling LFP generated by a cortical network model. A Sketch of point-neuron network model [1]. B Spikes of point neurons in the network for spontaneous and evoked activity. C Populations of multi-compartment neurons acting as LFP signal generators. D Depth-resolved LFP predicted using the hybrid scheme.

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Acknowledgements

This research was partially funded by EU Grant 604102 (HBP), EU Grant 269921 (BrainScaleS), the Helmholtz portfolio theme SMHB, the Juelich Aachen Research Alliance (JARA), and the Research Council of Norway (NFR, through ISP, NOTUR -NN4661K).

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Correspondence to Espen Hagen.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Hagen, E., Dahmen, D., Stavrinou, M. et al. Hybrid scheme for modeling local field potentials from point-neuron networks. BMC Neurosci 16, P67 (2015). https://doi.org/10.1186/1471-2202-16-S1-P67

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Keywords

  • Synaptic Input
  • Primary Visual Cortex
  • Hybrid Scheme
  • Local Field Potential
  • Cortical Network