- Poster presentation
- Open Access
The role of adaptation current in synchronously firing inhibitory neural networks with various topologies
© Rich et al. 2015
- Published: 18 December 2015
- Adaptation Current
- Neighbor Connection
- Small World Network
- Random Topology
- Connection Topology
Inhibitory neural networks have the capacity to fire synchronously depending strongly on synaptic current dynamics. Various types of inhibitory interneurons, including some with adaptation currents, are present in hippocampal circuits and are implicated in governing overall network pattern formation. However, the contribution of intrinsic cell firing patterns of interneurons to these patterns has not been fully investigated. Understanding how both synaptic and cellular properties contribute to the propensity for inhibitory neural networks to synchronize is thus an invaluable tool for investigating hippocampal network pattern formation. Through numerical simulation of large, spiking neuron, inhibitory networks, we investigate the role of the slow, adapting M-type K+ current in network pattern formation. This adapting current plays a role in hippocampal interneurons, including the OLM cells, in which the blockade of M-current by acetylcholine or other neurotransmitters switches the neuronal firing rate-current relation (f-I curve) from Type II to Type I. Other types of interneurons, such as fast-spiking PV cells, display Type II f-I curves without any adaptation current. Thus, we consider networks of three cell types: Type I neurons and Type II neurons that either contain  or do not contain an M-type K+ adaptation current. All cell types are modeled in the Hodgkin-Huxley formalism. Heterogeneity is introduced to the networks through randomized external applied current to the neurons. We vary network connection topologies using the Small World Network Paradigm  in order to systematically investigate the role of connectivity between local and random topologies.
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