- Poster presentation
- Open Access
Modulation of neural firing through intracellular ATP dynamics governed by energy feedback from the vascular system
© Chhabria and Chakravarthy 2015
- Published: 4 December 2015
- KATP Channel
- Local Field Potential
- Tonic Burst
- Neural Firing
- Cortical Pyramidal Neuron
We propose a simple model for neuro-glio-vascular interactions to emphasize on the role of energy feedback from the vascular system in brain's computations [1, 2]. In , we introduced a bidirectional communication within a detailed biophysical model of neuron-astrocyte-vessel. We now compress this model to just two modules: the neuron and the 'energy' module. The energy module is a lumped representation of the astrocyte-vessel system; it receives neural firing activity as input and controls intracellular neuronal energy (ATPi) levels as a feedback. The model comprises of a quadratic integrate and fire neuron with a dynamic threshold, V th , which further depends on the ATPi dynamics. V th is high during ATPi deficit, making the neuron least excitable and vice versa for high ATPi conditions. The underlying principle of modeling V th as a function of ATPi is based on the experiments describing the role of KATP channels in governing neural excitability . These channels are ATP-dependent potassium channels and are open when ATPi is low, resulting in a depolarized membrane potential of the neuron during metabolically compromised states such as hypoxia .
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