- Poster presentation
- Open Access
Induction and consolidation of calcium-based homo- and heterosynaptic potentiation and depression
BMC Neuroscience volume 16, Article number: P252 (2015)
Synaptic plasticity serves as the physiological foundation for learning and memory . While homosynaptic plasticity is associative learning or Hebbian-type plasticity, heterosynaptic plasticity reflects the synaptic change without direct stimulation, i.e. non-associative plasticity . However, heterosynaptic plasticity is an important mechanism preventing run-away synaptic dynamics and offers a potential mechanism to understand memory allocation [2, 3]. Experimental results show that the induction of heterosynaptic plasticity as well as homosynaptic plasticity depends on the postsynaptic calcium concentration . We propose that heterosynaptic plasticity can be induced by the postsynaptic calcium dynamics which can be triggered by the back propagation of action potentials.
However, homosynaptic plasticity has an early-phase (< 3 hours) and a late-phase state (> 8 hours) . Experiments show that an early-phase synaptic change can be transferred to a late-phase by the mechanisms of "synaptic tagging and consolidation" (STC) [5, 6]: (i) the changed synapse get tagged and (ii) a strong activation enables in the postsynaptic neuron the synthesis of plasticity-related proteins (PRP) which are transmitted back to the tagged synapse[5, 6]. We propose that the same STC mechanism consolidating homosynaptic changes are also able to consolidate heterosynaptic changes.
We combine a history spiking-dependent neuron  with calcium-based synaptic plasticity rule  and synaptic consolidation mechanism  to understand: (i) the mechanisms of inducing heterosynaptic plasticity by which the inactive synapse can change its weight through the postsynaptic calcium level triggered by the back propagation of the shared neuron; and (ii) of the consolidation of heterosynaptic changes based on the synaptic tagging and consolidation principle. For instance, a strong stimulus transmitted by a group of synapses induces and consolidates by the postsynaptic neuron heterosynaptic changes at other, unrelated synapses. Our study provides a further step of understanding how several mechanisms interact with each other to enable the formation of computational important long-term changes or memories.
Abraham WC: How long will long term potentiation last?. Phil. Trans. R. Soc. Lond. B. 2003, 358: 735-744.
Chistiakova M, Bannon NM, Bazhenov M, Volgushev M : Heterosynaptic plasticity: multiple mechansims and muliple roles. Neuroscientist. 2014, 20 (5): 483-498.
Rogerson T, Cai DJ, Frank A, Sano Y, Shobe J, et al: Synaptic tagging during memory allocation. Nat Rev Neurosci. 2014, 15: 157-169.
Malenka RC, Kauer JA, Zucker RS, Nicoll RA: Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission. Science. 1988, 242: 81-84.
Frey U, Morris R GM: Synaptic tagging and long-term potentiation. Nature. 1997, 385: 533-536.
Sajikumar S, Navakkode S, Frey JU: Identification of compartment-and Process-Specific Molecules Required for "Synaptic Tagging" during Long-Term Potentiation and Long-Term Depression in Hippocampal CA1. J Neurosci. 2007, 27 (19): 5068-5080.
Yamauchi S, Kim H and Shinomoto S: Elemental spiking neuron model for reproducing diverse firing patterns and predicting precise firing times. Front in Comput neurosci. 2011, 5 (42): 1-15.
Graupner M, Brunel N: Calcium-based plasticity model explains sensitivity of synaptic changes to spike pattern, rate and dendritic location. PNAS. 2012, 109 (10): 3991-3996.
Clopath C, Ziegler L, Vasilaki E, Buesing L, Gerstner W: Tag-Trigger-Consolidation: A Model of Early and Late Long-Term-Potentiation and Depression. PLoS CB. 2008, 4 (12): e1000248-
This research is funded by from the European Communities Seventh Framework Program FP7/2007-as well as from the Germany Ministry of Science Grant to the Göttingen Bernstein Center for Computational Neuroscience.
About this article
Cite this article
Li, Y., Kulvicius, T. & Tetzlaff, C. Induction and consolidation of calcium-based homo- and heterosynaptic potentiation and depression. BMC Neurosci 16 (Suppl 1), P252 (2015). https://doi.org/10.1186/1471-2202-16-S1-P252
- Back Propagation
- Postsynaptic Neuron
- Synaptic Change
- Plasticity Rule
- Synaptic Dynamic