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- Open Access
Synaptic transmission of spike trains with arbitrary interspike intervals
© Bird and Richardson 2015
- Published: 4 December 2015
- Synaptic Transmission
- Spike Train
- Neurotransmitter Release
- Firing Pattern
- Spike Time
Short-term synaptic depression, caused by depletion of releasable neurotransmitter vesicles, modulates the strength of neuronal connections in an activity-dependent manner [1, 2]. Quantifying the statistics of this form of synaptic transmission requires the development of stochastic models linking probabilistic neurotransmitter release with the spike-train statistics of the presynaptic population [3, 4]. A common approach has been to model the presynaptic spike train as either regular or a memory-less Poisson process  - few analytical results are available that describe the behaviour of a depressing synapse when the afferent spike train has more complex, temporally correlated statistics.
These results will allow for the incorporation of more complex and physiologically relevant firing patterns into future analytic studies of neuronal circuits and networks.
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