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Local interaction in retinal ganglion cell mosaics can generate a consistent spatial periodicity in cortical functional maps
BMC Neuroscience volume 16, Article number: P192 (2015)
Orientation map is one of the most studied functional maps in visual cortex, but the developmental mechanism of its consistent spatial periodicity is still elusive. Recently, a theoretical model suggested that a moiré interference pattern between ON and OFF retinal ganglion cell (RGC) mosaics can develop a quasi-periodic orientation map, but it is remained unclear how this can explain the constant periodicity of the maps . Here we suggest a developmental model that a simple local interaction in RGCs can generate a consistent spatial periodicity of orientation preference, by inducing (i) a hexagonal lattice structure in ON/OFF RGC mosaics and (ii) a constant alignment angle between them.
First, we introduced a developmental model of a monotypic RGC mosaic to show that a local repulsive interaction can generate a hexagonal structure (Figure 1A). Previously, in the model study of the pairwise interaction point process, it was suggested that a local interaction alone cannot develop a long-range order in the mosaic structure . We assumed a different type of local repulsive interaction that the cell positions can be gradually shifted by a repulsion from the neighbor cells and confirmed that this model can develop a long-range ordered structure that is well fitted to a hexagonal lattice.
Next, we assumed that there also exists a heterotypic repulsive interaction between ON and OFF RGC mosaics and examined how this can affect the alignment between the two mosaics (Figure 1B). When the inter-layer distance between ON/OFF mosaics was varied within a proper interval, the hexagonal structure was preserved in each mosaic, but the alignment angle (θ) between the two mosaics was restricted within a certain range of angles, and this induced a constant spatial periodicity in the ON/OFF interference pattern (Figure 1C). As observed in the moiré interference, we confirmed a consistent hexagonal periodicity in the cortical orientation map that are simulated by statistical wiring model from the developed RGC mosaics (Figure 1D,E) .
Our result suggests that a local repulsive interaction in RGC mosaics can generate a hexagonal structure in ON/OFF RGC mosaics and a restricted alignment between them. The interference between mosaics induces a consistent spatial periodicity in cortical orientation map as predicted by the moiré interference pattern.
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Jang, J., Paik, S. Local interaction in retinal ganglion cell mosaics can generate a consistent spatial periodicity in cortical functional maps. BMC Neurosci 16, P192 (2015). https://doi.org/10.1186/1471-2202-16-S1-P192
- Interference Pattern
- Retinal Ganglion Cell
- Hexagonal Structure
- Local Interaction
- Spatial Periodicity