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- Open Access
Local interaction in retinal ganglion cell mosaics can generate a consistent spatial periodicity in cortical functional maps
© Jang and Paik 2015
- Published: 18 December 2015
- Interference Pattern
- Retinal Ganglion Cell
- Hexagonal Structure
- Local Interaction
- Spatial Periodicity
Orientation map is one of the most studied functional maps in visual cortex, but the developmental mechanism of its consistent spatial periodicity is still elusive. Recently, a theoretical model suggested that a moiré interference pattern between ON and OFF retinal ganglion cell (RGC) mosaics can develop a quasi-periodic orientation map, but it is remained unclear how this can explain the constant periodicity of the maps . Here we suggest a developmental model that a simple local interaction in RGCs can generate a consistent spatial periodicity of orientation preference, by inducing (i) a hexagonal lattice structure in ON/OFF RGC mosaics and (ii) a constant alignment angle between them.
Next, we assumed that there also exists a heterotypic repulsive interaction between ON and OFF RGC mosaics and examined how this can affect the alignment between the two mosaics (Figure 1B). When the inter-layer distance between ON/OFF mosaics was varied within a proper interval, the hexagonal structure was preserved in each mosaic, but the alignment angle (θ) between the two mosaics was restricted within a certain range of angles, and this induced a constant spatial periodicity in the ON/OFF interference pattern (Figure 1C). As observed in the moiré interference, we confirmed a consistent hexagonal periodicity in the cortical orientation map that are simulated by statistical wiring model from the developed RGC mosaics (Figure 1D,E) .
Our result suggests that a local repulsive interaction in RGC mosaics can generate a hexagonal structure in ON/OFF RGC mosaics and a restricted alignment between them. The interference between mosaics induces a consistent spatial periodicity in cortical orientation map as predicted by the moiré interference pattern.
- Paik SB, Ringach DL: Retinal origin of orientation maps in visual cortex. Nat Neurosci. 2011, 14: 919-925.PubMedPubMed CentralView ArticleGoogle Scholar
- Hore VR a, Troy JB, Eglen SJ: Parasol cell mosaics are unlikely to drive the formation of structured orientation maps in primary visual cortex. Vis Neurosci. 2012, 29 (6): 283-299.PubMedPubMed CentralView ArticleGoogle Scholar
- Ringach DL: Haphazard wiring of simple receptive fields and orientation columns in visual cortex. J Neurophysiol. 2004, 92 (1): 468-476.PubMedView ArticleGoogle Scholar
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