- Poster presentation
- Open Access
Cell-type specific connectivity accounts for diverse in vivo functional roles of inhibitory neurons in V1
© Lee and Mihalas 2015
- Published: 18 December 2015
- Superficial Layer
- Inhibitory Neuron
- Gain Modulation
- Column Model
- Cortical Column
Inhibitory neurons have a large diversity , however functional roles of diverse subtypes have not been elucidated. We aim to help systematically addressing this question using large scale modeling and coarse graining between scales. Mesoscopic models of in vivo activity starting from structure have only recently become feasible making use of development of cortical column models , knowledge of connectivity [3, 4], scalable simulation tools [NEST] and robust population statistic techniques .
We also note that PV+ cell-mediating inhibition across columns is critical for regulating the responses over small spatial scales: e.g. induced by non-preferred stimulus (orientation). SST+ cell mediate inhibition across columns and allow contextual visual processing in V1.
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