- Poster presentation
- Open Access
Computational model of medial temporal lobe epilepsy
© Ahn et al. 2015
- Published: 18 December 2015
- Deep Brain Stimulation
- Temporal Lobe Epilepsy
- Small World Network
- Time Domain Signal
- Tonic Firing
Temporal lobe epilepsy represents a high proportion of whole epilepsy patients. Medial temporal lobe epilepsy (MTLE) is generated from internal structures like hippocampus, and patients with MTLE are poorly controlled by antiepileptic drugs . Recently, deep brain stimulation (DBS) that is to control seizure activity by stimulating epileptic zone is receiving attention as a new treatment of epilepsy. However, the exact mechanisms are still unclear and the current method is being developed relying on clinical experiences. Consequently, researches for etiology of disease along with seizure suppress mechanisms by electrical stimulation are very significant. These studies would be best progressed with complementary cooperation between in-vitro and in-vivo experiments, and computer simulations using a computational model.
In this paper, we propose a hippocampal network model which portrays seizure-like events (SLEs) recorded in in-vitro experiments. The model is composed of excitatory and inhibitory neurons interconnected following the well-known synaptic pathway to form a small world network . Each neuron is descripted by Izhikevich's model  and synaptic current is calculated based on conductance of a receptor. Short-term and long-term plasticity are also applied to every synapse . SLEs induced by 4-AP are divided into three regions according to time-frequency features. The first region is transition to ictal region by excitatory GABAergic drive , the second region is tonic firing region by synchronization due to recurrent excitation between principle neurons , and the last region is clonic bursting and termination region by GABA-mediated inhibitory mechanisms . Proposed model faithfully reproduces these phenomena by controlling synaptic input gain.
- Avoli M, D'Antuono M, Louvel J, Köhling R, Biagini G, Pumain R, D'Arcangelo G, Tancredi V: Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Prog Neurobiol. 2002, 68: 167-207.PubMedView ArticleGoogle Scholar
- Netoff TI, Clewley R, Arno S, Keck T, White JA: Epilepsy in small-world networks. J Neurosci. 2004, 24 (37): 8075-8083.PubMedView ArticleGoogle Scholar
- Izhikevich EM: Simple model of spiking neurons. IEEE Trans Neural Netw. 2003, 14 (6): 1569-1572.PubMedView ArticleGoogle Scholar
- Izhikevich EM, Gally JA, Edelman GM: Spike-timing dynamics of neuronal groups. Cereb Cortex. 2004, 14 (8): 933-944.PubMedView ArticleGoogle Scholar
- Staley KJ, Soldo BL, Proctor WR: Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science. 1995, 269: 977-981.PubMedView ArticleGoogle Scholar
- Ziburkus J, Cressman JR, Barreto E, Schiff SJ: Interneuron and pyramidal cell interplay during in vitro seizure-like events. J Neurophysiol. 2006, 95: 3948-3954.PubMedPubMed CentralView ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.