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- Open Access
The computational properties of a simplified cortical column model
BMC Neurosciencevolume 15, Article number: P92 (2014)
The mammalian neocortex generally has a repetitious, laminar structure and performs functions integral to higher cognitive processes, including sensory perception, memory, and coordinated motor output. What computations does this circuitry subserve, that might connect these unique structural elements with their biological function? Potjans and Diesmann  parameterize a four- layer, two cell-type (i.e excitatory and inhibitory) model of a cortical column. Beginning with their detailed model description, we implement their model using a displacement PDE (DiPDE) population statistic approach. This approach affords fast semi-analytic numerical method to solve equations describing homogeneous neuronal populations  (see also ).
This population statistic approach lends itself to quickly analyzing the response properties of population-scale dynamics of neural tissue. We use this strategy to examine the input-output relationship of the Potjans and Diesmann column model (see also ), in an attempt to uncover canonical computations  that it might implement. We find that excitatory perturbations to layers 4 (a site of primarily ”bottom-up” thalamic input in sensory areas) and 2/3 (a site of primarily ”top-down” cortical input) elicit an attenuated, additive perturbation in layer 23 activity, yet offset subtractively in their effect on layer 5 (see Figure 1). This computation might subserve, for example, an inferential update of prior experience with new sensory information. We generalize this finding by computing a linear kernel that describes the response of the column circuit to time varying stimuli.
Potjans TC, Diesmann M: The Cell-Type Specific Cortical Microcircuit: Relating Structure and Activity in a Full-Scale Spiking Network Model. Cerebral Cortex. 2014, 24 (3): 785-806. 10.1093/cercor/bhs358.
Iyer R, Menon V, Buice M, Koch C, Mihalas S: The Influence of Synaptic Weight Distri- bution on Neuronal Population Dynamics. PLoS Comput Biol. 2013, 9 (10): e1003248-10.1371/journal.pcbi.1003248.
Cain N, et al: Simulations of the statistics of firing activity of neuronal populations in the entire mouse brain. Neuroscience Meeting Planner. 2013, 488 (01): Society for Neuroscience
Wagatsuma N, Potjans T, Diesmann M, Fukai T: Layer-dependent attentional processing by top-down signals in a visual cortical microcircuit model. Frontiers in Computational Neuroscience. 2011, 5:
Douglas R, Martin K: Neuronal circuits of the neocortex. Annu. Rev. Neurosci. 2004, 27: 419-451. 10.1146/annurev.neuro.27.070203.144152.
This work was funded by the Allen Institute for Brain Science. The authors wish to thank the Allen Institute founders, Paul G. Allen and Jody Allen, for their vision, encouragement, and support.