Modeling task-specific manifestations of serotonin in basal ganglia using risk-based decision making
© Priyadharsini et al; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
We propose a significant role of the reduced 5HT levels  in addition to DA to accurately explain the observed sensitivity profile  (Refer Fig. 1B). Shown here is that the 5HT-DA model (α > 0) captures the experiment profile  better than just a DA model of BG (α = 0). This model infers that 5HT along with DA contributes to the PD patients' reward-punishment sensitivity (Fig. 1A,B).
- Priyadharsini BP, Ravindran B, Chakravarthy VS: Understanding the role of serotonin in basal ganglia through a unified model. Artificial Neural Networks and Machine Learning–ICANN 2012. 2012, Springer, 467-473.View ArticleGoogle Scholar
- Magdoom KN, Subramanian D, Chakravarthy VS, Ravindran B, Amari S, Meenakshisundaram N: Modeling basal ganglia for understanding Parkinsonian reaching movements. Neural Comput. 2011, 23 (2): 477-516. 10.1162/NECO_a_00073.View ArticlePubMedGoogle Scholar
- Bodi N, Keri S, Nagy H, Moustafa A, Myers CE, Daw N, Dibo G, Takats A, Bereczki D, Gluck MA: Reward-learning and the novelty-seeking personality: a between- and within-subjects study of the effects of dopamine agonists on young Parkinson's patients. Brain : a journal of neurology. 2009, 132 (Pt 9): 2385-2395.View ArticleGoogle Scholar
- Kish SJ, Tong J, Hornykiewicz O, Rajput A, Chang L-J, Guttman M, Furukawa Y: Preferential loss of serotonin markers in caudate versus putamen in Parkinson's disease. Brain. 2008, 131 (1): 120-131.PubMedGoogle Scholar
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