- Poster presentation
- Open Access
Network dynamics contribute to a gamma rhythm highly robust to synaptic variation
© Hauser and Reimers; licensee BioMed Central Ltd. 2014
- Published: 21 July 2014
- Inhibitory Neuron
- Gamma Oscillation
- Synaptic Conductance
- Dynamic Compensation
- Regular Spike
Dynamic homeostatic compensation in neural networks has recently attracted study. The gamma rhythm is often the focus of computational studies, as it is a local phenomenon and clinically significant: its disruption has been linked with mental illnesses such as schizophrenia and epilepsy. However little is known about dynamic compensation in relation to gamma rhythms. In (Reimers et al, in preparation) we observed that in all human brain genomics data sets, there is surprisingly high variability in mRNA levels for the key components of the GABA-A receptors, which are the mediators of fast inhibition. Further work showed that the variation was not compensated by substitution of different components of the same class of GABA-A receptor, suggesting at least a 20-fold variation in inhibitory signaling strength between individuals. Nevertheless most people seem to produce comparable gamma rhythms even with very different genetics.
We find that the modified model is much more robust to variation in synaptic conductance, even on the scale suggested by transcriptomic variation (Figure 1A, B). Additionally, we find that each of our significant modifications increases the close tracking of inhibition to excitation during the gamma oscillation, in which we see a high correlation in our modified version (Figure 1D, F). This tracking seems to be the core of the robustness and has recently been shown to be an important modulator of the gamma rhythm . The robustness of the modified model stems from network interaction rather than compensating parameters.
- Okaty BW, Miller MN, Sugino K, Hempel CM, Nelson SB: Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons. The Journal of Neuroscience. 2009, 29 (21): 7040-7052. 10.1523/JNEUROSCI.0105-09.2009.PubMed CentralView ArticlePubMedGoogle Scholar
- Atallah BV, Scanziani M: Instantaneous modulation of gamma oscillation frequency by balancing excitation with inhibition. Neuron. 2009, 62 (4): 566-577. 10.1016/j.neuron.2009.04.027.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.