Long-term plasticity determines the postsynaptic response to correlated afferents with multivesicular short-term synaptic depression
© Bird and Richardson; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
The firing rate of a neuron is largely determined by correlations in synaptic drive. Correlations in neurotransmitter release between different active sites arise from both synchronous activity in the presynaptic population and the number of independent release sites per neuron. Recent work has shown that the number of release sites on each neuron is modified during long-term plasticity . Such changes will modulate the effect of synchronous drive and therefore have a significant effect on the response of the postsynaptic cell.
These effects arise because, above a certain level of correlation, activity in the presynaptic population is overly strong resulting in wastage of the pool of releasable neurotransmitter. As the nervous system operates under metabolic constraints it is likely that this phenomenon provides an activity-dependent constraint on network architecture.
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