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BMC Neuroscience

Open Access

Information theoretical analysis of differences in information transmission in cerebellar Purkinje cells across species

  • Kirsty Kidd1Email author,
  • James M Bower1,
  • Daniel Polani1,
  • Neil Davey1 and
  • Volker Steuber1
BMC Neuroscience201415(Suppl 1):P40

https://doi.org/10.1186/1471-2202-15-S1-P40

Published: 21 July 2014

The dendrite of the cerebellar Purkinje cell is one of the most complex structures in the mammalian brain, receiving more than 150,000 synaptic inputs. It is also one of the most extensively modelled neurons in the mammalian brain, with theoretical analysis of the input-output relationships in its dendrite extending back 40 years. While most of this experimental and modelling work has been conducted using mammalian neurons, it has also often been noted that overall cerebellar structure as well as the general morphology of Purkinje cells has been highly conserved in all vertebrate species. The work described here seeks to identify conserved features of Purkinje cell function by examining the relationship between structure and function in a range of vertebrate species from fish to mammals.

This study is based on passive compartmental models constructed from anatomical reconstructions of Purkinje cells obtained from fish, reptiles, birds and mammals. Morphologically, while the Purkinje cells of each of the species are flattened structures and appear to have the same geometrical relationship to other elements of the cerebellar cortical circuitry, the dendrites of birds, alligators and mammals have a much more highly articulated dendritic branching structure than the dendrites of fish and turtles. In previous studies of the passive electrical properties of these dendrites [1], we have shown that there is surprisingly little difference in voltage attenuation between the species. In this extension of the comparative work, we have applied techniques from information theory to quantify possible similarities and differences in the effect of synaptic inputs on the passive properties of the dendrite. Specifically, we propose a new technique to find the time window that best predicts an output spike train given the input, and have used the weighted context tree method [2] to estimate the synaptic information efficacy (SIE) of individual synapses found in different locations on the dendritic tree.

Authors’ Affiliations

(1)
Science and Technology Research Institute, University of Hertfordshire

References

  1. Kidd K, Cornelis H, Bower JM, Polani D, Davey N, Steuber V: The implications of evolutionary changes in the dendritic morphology of cerebellar Purkinje cells for information processing [abstract]. BMC Neurosci. 2013, 14 (Suppl 1): P373-PubMed CentralGoogle Scholar
  2. London M, Schreibman A, Häusser M, Larkum ME, Segev I: The information efficacy of a synapse. Nat Neurosci. 2002, 5 (4): 332-340. 10.1038/nn826.View ArticlePubMedGoogle Scholar

Copyright

© Kidd et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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