Large-scale spiking circuit simulation of spatio-temporal dynamics in superior colliculus
© Veale et al; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
We present computational simulations of the intrinsic circuitry of the superior colliculus using large-scale spiking neural circuit models. We reproduce recent results from slice experiments that showed different spatio-temporal patterns of interaction within the visual layers versus the eye-movement related layers of the superior colliculus. Specifically, the receptive fields of neurons in the visual layers implement a “center-surround” pattern of spatial competition, and furthermore additional input within the central region sums super-linearly. In contrast, the receptive fields of neurons in the motor-related regions implement spatially symmetric fields of overlaid excitation and inhibition, and additional inputs sum linearly. Our simulations investigate the circuit mechanisms and dynamics that differentiate the computational roles of these distinct but related regions.
This contrasts with the motor-related intermediate layers (Figure 1B), whose response to stimulation was best explained by both spatial and temporal symmetry between inhibitory and excitatory neural connections. Overall, the regions seem to have taken advantage of both spatial and temporal dynamics in their connections to specialize their computational function: The visual layers seem geared towards spatial competition and strengthening of salient stimuli, whereas the motor-related regions seem geared towards broad and long-term integration of input.
R.V. is a GRF and IGERT; this research was supported by NSF GROW/JSPS Strategic Program.
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