Local and long-range phase-amplitude coupling in a cortical spiking network model
© Donhauser and Baillet; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
Phase-amplitude coupling (PAC) between neural oscillations in different frequency bands has been observed in population recordings of the hippocampus and neocortex [1, 2]. Specifically, bursts of gamma (>30 Hz) oscillations are often found to be phase-locked to a slower oscillation in the theta range (4-8 Hz), raising questions about the mechanisms and computational consequences of this pattern. Recently, inter-areal gamma synchronization was also found to be systematically modulated by theta rhythms . We study mechanisms for these experimental findings and their potential role in long-range inter-areal coupling using spiking neuron network models.
Using dynamical systems theory, bursting has previously been analyzed in detail for single neuron dynamics , requiring interaction of fast and slow adapting variables, driving the neuron through alternations of active (limit cycle) and resting (stable equilibrium) periods. On the population level, bursting can be studied within the same framework, treating average synaptic activity and time courses as slow/fast variables. Our model (Panel A) is based on observations of dynamically distinct interneuron populations in the cortex, namely fast-spiking, non-adapting (FS) and adapting interneurons (low-threshold spiking, LTS) exhibiting fast and slow synaptic time courses . Coupled with a population of principal cells (regular spiking, RS), this network displays spontaneous phase-amplitude coupling as sparsely synchronized population bursts. Feed-forward connections between populations of this type lead to theta modulated gamma synchronization (Panel B and C).
- Canolty R, Edwards E, Dalal S, Soltani M, Nagarajan S, Berger M, Barbaro N, Knight RT: High Gamma Power is Phase-Locked to Theta Oscillations in Human Neocortex. Science. 2009, 313: 1626-1628.View ArticleGoogle Scholar
- Colgin LL, Denninger T, Fyhn M, Hafting T, Bonnevie T, Jensen O, Moser MB, Moser EI: Frequency of gamma oscillations routes flow of information in the hippocampus. Nature. 2009, 462: 353-7.View ArticlePubMedGoogle Scholar
- Bosman CA, Schoffelen JM, Brunet N, Oostenveld R, Bastos AM, Womelsdorf T, Rubehn B, Stieglitz T, De Weerd P, Fries P: Attentional stimulus selection through selective synchronization between monkey visual areas. Neuron. 2012, 75: 875-88.PubMed CentralView ArticlePubMedGoogle Scholar
- Izhikevich E, Hoppensteadt F: Classification of Bursting Mappings. International Journal of Bifurcation and Chaos. 2004, 11: 3847-3854.View ArticleGoogle Scholar
- Beierlein M, Gibson JR, Connors BW: Two dynamically distinct inhibitory networks in layer 4 of the neocortex. Journal of Neurophysiology. 2003, 90: 2987-3000.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.