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Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia
© Hashemi et al; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
This shows that neglecting inhibitory action in the cortex but considering thalamic GABAergic action suffices to reproduce the data. From a modeling point of view, our reduced mathematical model is low dimensional and remains analytically treatable while still being adequate to reproduce observed changes in EEG rhythms. Moreover, it is shown that the propofol concentration acts as a control parameter of the system and that propofol-induced changes in the stationary states of the model system lead to changes in the corresponding nonlinear gain function that result in EEG power modulation: increases of power over the frontal region can be caused by an increase in the gain function of thalamocortical network. The results suggest that intra-thalamic inhibition from reticular neurons to relay cells plays an important role in the generation of the characteristic EEG patterns seen during general anesthesia.
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