Stabilizing working memory in spiking networks with biologically plausible synaptic dynamics
BMC Neuroscience volume 15, Article number: P157 (2014)
Behavior often requires remembering continuously structured information, e.g. positions in the visual field, over delay periods of up to seconds. How can a neural circuit reliably store this information using biophysical mechanisms that work on timescales of milliseconds? Recurrently connected networks with continuous attractors [1, 2] provide a solution by creating a self-sustained bump-shaped neural activity profile that can be positioned along a continuous degree of freedom. This freedom of position, however, renders the activity bump highly sensitive to the sources of variability expected in cortical networks: low connection probabilities, suboptimal synaptic weights or heterogeneity of neuronal parameters. These can lead to a quick drift of the bump position and thus detrimental loss of acuity of the encoded memory. Short-term facilitation (STF) stabilizes drift in continuous attractors, as shown recently in simplified neural network models [3, 4].
In neurons STF acts by dynamically regulating neurotransmitter release, mainly onto NMDA channels, however these simplified models neglect detailed synaptic integration mechanisms. It is thus unclear whether comparable stabilization can be achieved with biologically plausible synaptic dynamics, which limit the effects of STF, like activity dependent saturation of NMDA receptors  and conductance based synaptic transmission.
To address this issue we combined two influential classes of models: spiking models of cortical networks with conductance based synapses and detailed dynamics of NMDA receptors , and models of short-term dynamics of presynaptic transmitter release  (see Figure 1). We derive analytical predictions for the amount of drift expected from the different sources of variability described above and investigate the extent to which STF can alleviate their detrimental influence, allowing us to place constraints on the combinations of network and synapse properties. Thus, we demonstrate the extent to which STF alone can stabilize the temporal evolution of continuous attractors in biologically plausible networks and clarify whether additional stabilization mechanisms are necessary to make these models candidates for functional working memory.
Wimmer K, Nykamp DQ, Constantinidis C, Compte A: Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory. Nature Neuroscience. 2014
Compte A, Brunel N, Goldman-Rakic PS, Wang XJ: Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. Cerebral Cortex. 2000, 10: 910-923. 10.1093/cercor/10.9.910.
Itskov V, Hansel D, Tsodyks M: Short-Term Facilitation may Stabilize Parametric Working Memory Trace. Frontiers in Computational Neuroscience. 2011, 5: 40-
Hansel D, Mato G: Short-term plasticity explains irregular persistent activity in working memory tasks. The Journal of Neuroscience. 2013, 33 (1): 133-49. 10.1523/JNEUROSCI.3455-12.2013.
Markram H, Wang Y, Tsodyks M: Differential signaling via the same axon of neocortical pyramidal neurons. Proceedings of the National Academy of Sciences. 1998, 95 (9): 5323-8. 10.1073/pnas.95.9.5323.
Research supported by the European Research Council (Agreement #268 689, MultiRules) and the Swiss National Science Foundation (Agreement #200020_147200).
About this article
Cite this article
Seeholzer, A., Deger, M. & Gerstner, W. Stabilizing working memory in spiking networks with biologically plausible synaptic dynamics. BMC Neurosci 15 (Suppl 1), P157 (2014). https://doi.org/10.1186/1471-2202-15-S1-P157
- NMDA Receptor
- Synaptic Weight
- Cortical Network
- Connection Probability
- NMDA Channel