Kisspeptin mediation of estradiol-induced secretion of luteinizing hormone and prolactin
© Toporikova et al; licensee BioMed Central Ltd. 2014
Published: 21 July 2014
In females, ovulation is coordinated by a complex set of interactions between the hypothalamus, the anterior pituitary and the gonads. Luteinizing hormone (LH) and prolactin (PRL) are pituitary hormones that have complementary roles in reproduction. There is a surge of both hormones prior to ovulation that is essential for adequate reproduction and can be mimicked by estradiol (E2) treatment in ovariectomized (OVX) rats , . Both the preovulatory and the E2-induced LH and PRL surges in OVX rats occur at the same time of the day, indicating that circadian signals originating in the suprachiasmatic nucleus (SCN) must provide input to coordinate both LH and PRL secretion, and that response to this input depends on the steroid milieu. Kisspeptin (KISS) is the most potent stimulator of LH release and it has been recently demonstrated to also stimulate PRL release. There are two KISS neuronal populations in the rodent brain, located in the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The ARC population coexpress kisspeptin, neurokinin B and dynorphin and are called KNDy neurons.
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