- Oral presentation
- Open Access
Parameter correlations maintaining bursting activity
© Doloc-Mihu and Calabrese; licensee BioMed Central Ltd. 2014
- Published: 21 July 2014
- Central Pattern Generate
- Maximal Conductance
- Functional Activity Group
- Realistic Instance
- Apply Principal Component Analysis
In this study, we focused on the role of correlated conductances in the robust maintenance of functional bursting activity. Recent experimental and computational studies suggest that linearly correlated sets of parameters (intrinsic and synaptic properties of neurons) allow central pattern generating (CPG) neurons to produce and maintain their rhythmic activity regardless of changing internal and external conditions. However, the mechanisms that allow multiple parameters to interact, thereby producing and maintaining rhythmic network activity, are less clear.
A least square fit regression line (3D Orthogonal Distance Regression (ODR) line) to each group of isolated neurons (Figure 1 C) showed a tendency for the realistic instances to be at the high values on all axes and a tendency of the regular/not realistic instances to be at the low and middle values on all axes. From our analysis, it appears that none of the ḡLeak , ḡK2, or ḡP parameters is sufficient by itself to produce regular and realistic isolated neuron instances, but they must work together (in linear combination) in almost equal amounts towards producing the respective instances. Experimental studies have shown that period is a key attribute influenced by modulatory inputs and temperature variations in heart interneurons. Thus, we explored the sensitivity of period to changes in maximal conductances of ḡLeak, ḡK2, and ḡP, and we found that for our realistic isolated neurons the effect of these parameters on period could not be assessed because when varied individually bursting activity was not maintained. Current studies are focused on determining which parameters can, when varied, smoothly control period, while maintaining bursting activity.
Work supported by the National Institute Health Grant NS085006 to R.L.Calabrese.
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