Patterns in network activity and information processing in a detailed computer model of the cerebellar granular layer
BMC Neuroscience volume 15, Article number: O2 (2014)
In the cerebellar cortex, the granular layer is at the first stage of processing information from other brain regions delivered via mossy fibers. The major components of this neural network are numerous and tiny granule cells (GrC), which are the only excitatory neurons, and Golgi cells (GoC) that provide the only inhibitory inputs to GrCs. Despite such structural simplicity, many questions about their functions remain unanswered.
Here we investigate the signal transformation property of the granular layer neural network with our three-dimensional large-scale and detailed computer model, composed of the biophysically detailed ~8×105 GrC and ~2000 GoC models with their physiological synaptic and electrical connectivity. With background and constant mossy fiber inputs, the model shows network-wide oscillations driven by the synchronized GoC firing, as in previous simulation and experimental studies [1–3]. Oscillation frequency was usually higher than the Golgi cell-firing rate, as some GoCs exhibited cycle skipping. With more physiological and diverse paradigms of mossy fiber stimulation, we could observe interesting patterns which hint that this oscillation and rate coding synergistically contribute to the network outputs. For example, when the mossy fiber stimulation is spatially limited, there is anti-correlation in the GrC spike count between the stimulated and unstimulated region, suggesting center-surround “receptive fields” , while the oscillation persists and opens time windows for well-timed spikes  (Figure 1). Our results suggest how the complex dynamics of the granular layer network due to cellular and synaptic properties can contribute to its rich information processing.
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Kumar, S., Hong, S. & De Schutter, E. Patterns in network activity and information processing in a detailed computer model of the cerebellar granular layer. BMC Neurosci 15 (Suppl 1), O2 (2014). https://doi.org/10.1186/1471-2202-15-S1-O2
- Receptive Field
- Cerebellar Cortex
- Granular Layer
- Rate Code
- Mossy Fiber