- Poster presentation
- Open Access
Epileptic spike-wave discharges in a spatially extended thalamocortical model
© Taylor et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Anatomical Connectivity
- Seizure State
- Cortical Compartment
- Pulse Perturbation
- Cortical Focus
Generalised spike-wave discharges (SWD), detectable on the electroencephalogram (EEG), are a hallmark of typical absence seizures. Several mechanisms of transmission have been proposed for SWD seizures including the centrencephalic theory, the corticoreticular theory, and the cortical focus theory . Experimental evidence suggests that seizures rapidly generalise through cortico-cortical and thalamo-cortical pathways from an excitable cortical 'focus' . Further evidence for a cortical focus comes from recent experimental results which show that stimulations to different cortical regions can elicit generalised SWD, however, the amplitude of the required stimulus varies from one region to another .
Based on known anatomical connectivity between the thalamus and cortex (Figure. 1A), we develop a macroscopic model of transitions between inter-ictal and ictal SW dynamics to investigate the cortical focus theory. Single pulse perturbations of sufficient amplitude can drive the model into the seizure state, i.e. the dynamics are excitable. Mechanistically, the stimuli transiently drive the cortical subsystem beyond a saddle-node bifurcation (c.f. ).
- Meeren H, van Luijtelaar G, Lopes da Silva F, Coenen A: Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory. Arch Neurol. 2005, 62 (3): 371-376. 10.1001/archneur.62.3.371.View ArticlePubMedGoogle Scholar
- Zheng T, Obrien T, Morris M, Reid C, Jovanovska V, OBrien P, van Raay L, Gandrathi A, Pinault D: Rhythmic neuronal activity in S2 somatosensory and insular cortices contribute to the initiation of absence-related spike-and-wave discharges. Epilepsia. 2012, 53 (11): 1948-58. 10.1111/j.1528-1167.2012.03720.x.View ArticlePubMedGoogle Scholar
- Taylor PN, Baier G: A spatially extended model for macroscopic spike-wave discharges. J Comput Neurosci. 2011, 31 (3): 679-684. 10.1007/s10827-011-0332-1.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.