Volume 14 Supplement 1
Dynamics of the thalamo-cortical system driven by pulsed sensory stimulation
© Weigenand et al; licensee BioMed Central Ltd. 2013
Published: 8 July 2013
There exists a large body of evidence pointing to an essential role of sleep in memory consolidation [1–3]. In particular non-REM sleep seems to be important for consolidating declarative memories . Boosting the so-called slow oscillations (<1 Hz) during non-REM sleep via transcranial electric stimulation leads to a potentiation of memory . It has also been demonstrated that slow oscillations can be induced by optogenetic, magnetic and acoustic stimulation [6–8]. Here we present data from human sleep studies and modeling results on the thalamo-cortical system under sensory stimulation, that give new clues for effective stimulation protocols. We use a population model that exhibits important features of brain activity during non-REM sleep, e.g. spindles, cortical
slow oscillations with gamma activity and clock-like delta oscillations. The model aims at reproducing evoked responses of auditory and visual stimuli at several frequencies. We extend previous results on the phase-dependent response of isolated cortex  to stimuli which are time-locked to spindle and slow oscillation events and test the hypothesis that the main factor determining thalamic gating properties in non-REM sleep is the phase of the cortical slow oscillation.
- Stickgold R: Sleep-dependent memory consolidation. Nature. 2005, 437 (7063): 1272-1278. 10.1038/nature04286.View ArticlePubMedGoogle Scholar
- Diekelmann S, Born J: The memory function of sleep. Nat Rev Neurosci. 2010, 11 (2): 114-126.PubMedGoogle Scholar
- Marshall L, Born J: The contribution of sleep to hippocampus-dependent memory consolidation. Trends Cogn Sci. 2007, 11 (10): 442-450. 10.1016/j.tics.2007.09.001.View ArticlePubMedGoogle Scholar
- Plihal W, Born J: Effects of early and late nocturnal sleep on declarative and procedural memory. J Cognitive Neurosci. 1997, 9 (4): 534-547. 10.1162/jocn.1922.214.171.1244.View ArticleGoogle Scholar
- Marshall L, Helgadottir H, Mölle M, Born J: Boosting slow oscillations during sleep potentiates memory. Nature. 2006, 444 (7119): 610-613. 10.1038/nature05278.View ArticlePubMedGoogle Scholar
- Massimini M, Ferrarelli F, Esser SK, Riedner BA, Huber R, Murphy M, Peterson MJ, Tononi G: Triggering sleep slow waves by transcranial magnetic stimulation. Proc Natl Acad Sci USA. 2007, 104 (20): 8496-8501. 10.1073/pnas.0702495104.PubMed CentralView ArticlePubMedGoogle Scholar
- Kuki T, Ohshiro T, Ito S, Ji Z, Fukazawa Y, Matsuzaka Y, Yawo H, Mushiake H: Frequency-dependent entrainment of neocortical slow oscillation to repeated optogenetic stimulation in the anesthetized rat. Neurosci Res. 2012Google Scholar
- Ngo HVV, Claussen JC, Born J, Mölle M: Induction of slow oscillations by rhythmic acoustic stimulation. J Sleep Res. 2013, 22: 22-31. 10.1111/j.1365-2869.2012.01039.x.View ArticlePubMedGoogle Scholar
- Weigenand A, Martinetz T, Claussen JC: The phase response of the cortical slow oscillation. Cogn Neurodyn. 2012, 6 (4): 367-375. 10.1007/s11571-012-9207-z.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.