Poster presentation | Open | Published:
Dynamics of the thalamo-cortical system driven by pulsed sensory stimulation
BMC Neurosciencevolume 14, Article number: P67 (2013)
There exists a large body of evidence pointing to an essential role of sleep in memory consolidation [1–3]. In particular non-REM sleep seems to be important for consolidating declarative memories . Boosting the so-called slow oscillations (<1 Hz) during non-REM sleep via transcranial electric stimulation leads to a potentiation of memory . It has also been demonstrated that slow oscillations can be induced by optogenetic, magnetic and acoustic stimulation [6–8]. Here we present data from human sleep studies and modeling results on the thalamo-cortical system under sensory stimulation, that give new clues for effective stimulation protocols. We use a population model that exhibits important features of brain activity during non-REM sleep, e.g. spindles, cortical
slow oscillations with gamma activity and clock-like delta oscillations. The model aims at reproducing evoked responses of auditory and visual stimuli at several frequencies. We extend previous results on the phase-dependent response of isolated cortex  to stimuli which are time-locked to spindle and slow oscillation events and test the hypothesis that the main factor determining thalamic gating properties in non-REM sleep is the phase of the cortical slow oscillation.
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