- Poster presentation
- Open Access
Leader neurons drive spontaneous and evoked activation patterns in cortical networks
© Pasquale et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Animal Model
- Propagation Pattern
- Activation Pattern
- Spatial Location
- Special Role
Recent studies about the generation and propagation of coordinated activity in cultured neuronal networks reported the existence of privileged neurons that consistently fire earlier than others at the onset of synchronized bursting events (or network bursts, NB), which have been termed major burst leaders (MBL) . At the same time, by stimulating the network from different channels one can obtain very different responses, not only in size and delay but also in the activation order of the responding neurons .
We electrically stimulated rat cortical networks cultured on micro-electrode arrays from different locations, either MBL or non-MBL. We evaluated the intensity and the delay of responses from either MBL or non-MBL and we also compared the spontaneous and the evoked activation patterns.
To summarize, we demonstrated that MBLs do not only drive the propagation of coordinated spontaneous activations, but also play a special role in coordinating and driving the evoked bursts of activity.
The research leading to these results has received funding from the European Union's Seventh Framework Program (ICT-FET FP7/2007-2013, FET Young Explorers scheme) under grant agreement n° 284772 BRAINBOW.
- Ham MI, Bettencourt LM, McDaniel FD, Gross GW: Spontaneous coordinated activity in cultured networks: analysis of multiple ignition sites, primary circuits, and burst phase delay distributions. J Comput Neurosci. 2008, 24 (3): 346-357. 10.1007/s10827-007-0059-1.View ArticlePubMedGoogle Scholar
- Shahaf G, Eytan D, Gal A, Kermany E, Lyakhov V, Zrenner C, Marom S: Order-based representation in random networks of cortical neurons. PLoS Comput Biol. 2008, 4 (11): e1000228-10.1371/journal.pcbi.1000228.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.