Volume 14 Supplement 1

Abstracts from the Twenty Second Annual Computational Neuroscience Meeting: CNS*2013

Open Access

How do channel densities and various time constants affect the dynamic gain of a detailed model of a pyramidal neuron?

  • David Hofmann1, 2Email author,
  • Andreas Neef1, 2,
  • Ilya Fleidervish3,
  • Michael Gutnick4 and
  • Fred Wolf1, 2
BMC Neuroscience201314(Suppl 1):P419


Published: 8 July 2013

The axon initial segment (AIS) controls the transformation of dendrosomatic synaptic input into spike output and the backpropagation of action potentials into the dendrites due to its lower spike initiation threshold. Channel density and kinetics can both contribute to this low threshold. However, the nature of such threshold differences is unknown and topic of current debates [13].

Dynamical response properties give a constraint on the AIS function. Here we study the dynamical response properties of a detailed multi compartment NEURON [4] model that well reproduces the sodium concentration changes in the AIS and soma generated by action potential firing in a layer 5 pyramidal cell [2].

To study these properties, we inject different current stimuli into the soma. These are constant currents and Gaussian noise currents as studied in [5]. We vary the sodium and potassium channel densities at the axon initial segment as well as the sodium activation time constant taum. Furthermore, we study the influence of input current parameters as mean, variance and correlation time. We then calculate the dynamic rate response of a population of independent neurons. This is described at linear order by a filter function with frequency dependent gain as done by [5].

The f-I curves show that the neuron model under investigation is of type I. This holds true for all channel densities tested. The cut-off frequency appears insensitive to AIS channel density.

Authors’ Affiliations

Bernstein Center for Computational Neuroscience Göttingen
Max Planck Institute for Dynamics and Self-Organization
Ben-Gurion University of the Negev
Hebrew University of Jerusalem


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© Hofmann et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.