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- Open Access
Effect of cortex inactivation on spontaneous activity of cells in perigeniculate and dorsal lateral geniculate nuclei
© Rogala et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Firing Rate
- Cortical Area
- Spontaneous Activity
- Spike Train
- Single Neuron
The cortical influence on spontaneous activity of single neurons in the dorsal lateral geniculate (LGN) and perigeniculate (PGN) nuclei were investigated in awake cats by means of reversible cooling of cortical areas 17 and 18 . We analyzed subtle changes of the statistical properties of spike trains. To understand their nature we investigated statistics of firing rate (FR), mean inter-spike interval (ISI), bursting rate (BR), mean intra-burst inter-spike interval (IBISI), mean number of spikes per burst (SPB) and mean burst duration (BD)[2, 3].
These results indicate that recurrent inhibition from PGN may play a homeostatic role in the cortico-thalamic loop by restricting thalamic oscillations within their natural functional range . The buffering role of PGN may explain why the massive, direct cortical projection to LGN neurons induces only small, highly-tuned effects during spontaneous activity.
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