- Poster presentation
- Open Access
Realistic simulations of local field potentials in a slice
© Chintaluri et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Realistic Simulation
- Hybrid Strategy
- Local Field Potential
- Ground Truth Data
- Potential Profile
The two key elements of realistic simulation of LFP are plausible model of neural activity, and the physical properties of the setup, tissue, and electrodes. To reduce the computational burden yet obtain a trustful rendering of LFP in specific experimental context different strategies have been tried. For instance, using total synaptic activity from a population of spiking neurons as a proxy for LFP, or hybrid strategies with network simulations of spiking neurons followed by computation of contributions to LFP from single cells driven by pre-calculated network dynamics. Tests of those strategies are impossible without ground-truth data including all the necessary components.
We modeled 3 different conductivity profiles within the slice and the saline:
i) 'no saline' case: slice and saline with the same conductivity of 0.3 mS/cm
ii) 'hom+iso+saline': homogeneous and isotropic slice of conductivity 0.3 mS/cm, saline: 3.0 mS/cm
iii) 'inhom+anis+saline': inhomogeneous and anisotropic slice with conductivity profiles for the layers taken as mean values from .
We see that the inclusion of slice setup noticeably modifies the observed activity as both the amplitude and shape of the potential profile is changed (Figure 1B). However, inclusion of inhomogeneity and anisotropy in the computations does not lead to substantial changes of the profile. Indeed, inaccurate estimation of conductivity (see variability of results in ) will in general introduce bigger errors than in assuming homogeneous and isotropic tissue.
Research funded from grants IP2011 030971, N N303 542839, FP7-PEOPLE-2010-ITN 264872 NAMASEN, POIG.02.03.00-00-018/08 POWIEW
- Traub RD, Contreras D, Cunningham MO, Murray H, Lebeau FE, Roopun A, Bibbig A, et al: A single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles and epileptogenic bursts. J Neurophysiol. 2005, 93 (4): 2194-2232.View ArticlePubMedGoogle Scholar
- Takakuni Goto, Rieko Hatanaka, Takeshi Ogawa, Akira Sumiyoshi, Jorge Riera, Ryuta Kawashima: An Evaluation of the Conductivity Profile in the Somatosensory Barrel Cortex of Wistar Rats. J Neurophysiol. 2010, 104: 3388-3412. 10.1152/jn.00122.2010.View ArticleGoogle Scholar
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