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BMC Neuroscience

Open Access

Probabilistic inference of synaptic dynamics in neocortical microcircuits

BMC Neuroscience201314(Suppl 1):P403

https://doi.org/10.1186/1471-2202-14-S1-P403

Published: 8 July 2013

Short-term synaptic plasticity (STP) is highly varied across brain area, cortical layer, cell type, and developmental stage (Reyes & Sakmann 1999). This variability is probably not coincidental and since synaptic dynamics shape neural computations, it suggests an important role of STP in neural information processing (Abbott & Regehr 2004). Therefore, an accurate description of STP is a key step towards a comprehensive understanding of neural systems. Many phenomenological STP models have been developed (Markram et al. 1998), but they have typically been fitted to experimental data using least-mean-square methods. With the Tsodyks-Markram model, we find that for typical synaptic dynamics such fitting procedures may give erratic outcomes. A Bayesian formulation based on a Markov Chain Monte Carlo method was introduced as a solution. This formulation provides the posterior distribution over the model parameters given the data statistics. We discovered that standard STP electrophysiology protocols yielded wide distributions over some model parameters. Based on this result we propose experimental protocols to more accurately determine model parameters. Next, the model parameters were inferred using experimental data from three different neocortical excitatory connection types: Pyramidal Cell-Pyramidal Cell (PC-PC), Pyramidal Cell-Basket Cell (PC-BC) and Pyramidal Cell-Martinotti Cell (PC-MC), (see Figure 1). This disclosed connection-specific distributions, which we used to classify synapses. This approach to determining connection-specific synaptic dynamics provides a more comprehensive representation of STP and unveils novel features from existing data.
Figure 1

Posterior distributions of STP parameters from experimental data from visual cortex layer-5. (A) Sample experimental STP traces are shown for PC-PC (red), PC-BC (green), and for PC-MC (blue) connections. (B) Marginalized posterior distributions obtained using slice sampling from the three different excitatory connections show connection-specific distributions. Light colored lines show individual distributions, while dark colored lines correspond to their average.

Authors’ Affiliations

(1)
Neuroinformatics and Computational Neuroscience Doctoral Training Centre, University of Edinburgh
(2)
Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh
(3)
The Research Institute of the McGill University Health Centre, Department of Neurology and Neurosurgery, McGill University

References

  1. Reyes A, Sakmann B: Developmental switch in the short-term modification of unitary EPSPs evoked in layer 2/3 and layer 5 pyramidal neurons of rat neocortex. J Neurosci. 1999, 19 (10): 3827-3835.PubMedGoogle Scholar
  2. Abbott LF, Regehr W: Synaptic computation. Nature. 2004, 432 (7010): 796-803.View ArticleGoogle Scholar
  3. Markram H, Wang Y, Tsodyks M: Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci USA. 1998, 95 (9): 5323-5328. 10.1073/pnas.95.9.5323.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Costa et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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