- Poster presentation
- Open Access
Distinct roles of inotropic and metabotropic glutamate receptors in rhythmic activity generated by pre-Botzinger complex
© Davis and Toporikova; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Central Nervous System
- Glutamate Receptor
To keep up with oxygen demands, the central nervous system regulates frequency of respiratory rhythm. The inspiratory phase of the respiratory rhythm originates in the pre-Bötzinger complex (preBötC), a region of the ventrolateral medulla. preBötC neurons generate stable rhythmic output when isolated from the rest of respiratory column. The frequency of the respiratory rhythm is modulated via release of excitatory neuromodulators by the Raphe nucleus. The respiratory rhythm observed in the preBötC depends on excitatory neurotransmission between neurons in the population, since blocking excitatory neurotransmission eliminates a coordinated rhythm at the level of the preBötC.
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