Heterogeneous connectivity can positively and negatively modulate the correlation between neural representations
© Chou et al; licensee BioMed Central Ltd. 2013
Published: 8 July 2013
Here, we show that the correlation between odor representations can be either decreased or increased in a model of the antennal lobe given the identical heterogeneous glomerular innervation of local neurons (LNs). The investigation of glomerular innervation of LNs confirmed that whereas some LNs innervate to only a few glomeruli, others innervate many and yet others to almost all glomeruli . Our simulation results showed that the different inputs of odorant-evoked activity patterns in SNs can be transformed into separated or joined PN representations of odor pairs in the identical circuits of LNs innervating all or part of glomeruli (Figure 1D, E). Our main contribution is grounded in the observation that selectively heterogeneous glomerular innervation of LNs may selectively inhibit particular sets of PNs, thereby reducing the high-dimensional inputs to lower dimensional activity of a glomerular circuit and thus modulating the dissimilarity or correlation between information encoded in PNs. Our analysis suggests that this connection heterogeneity may indeed be a key to resolve the conflicting functions enhancing the discriminating of odor representations (increasing correlation) and being robust against noise (decreasing the correlation between odor stimuli consisting of same odorants but being blurred by noise) in olfactory processing.
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