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Scale-free dynamics in human neonatal cortex following perinatal hypoxia
© Roberts et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Burst Size
- Average Shape
- Cortical Slice
- Burst Suppression
- Simple Dynamical Model
Complications at birth can interrupt blood supply to the baby, leading to hypoxia in the neonatal cortex. Once oxygen supply resumes, cortical activity follows a stereotypical recovery sequence that includes a period termed burst suppression, during which the EEG exhibits sudden, irregular fluctuations of highly variable size and shape. Clinical outcome depends critically on this phase, ranging from complete recovery to permanent cognitive or motor disability and even death. Despite its importance in the recovery process, burst suppression's mechanisms remain poorly understood, and objective diagnostics are needed to guide treatment .
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