Neuronal morphology as an instrument for information coding: studying the influence of axonal radius and branching points

Normally a wide range of constant current stimuli, applied to one end of a simple cylindrical axon, leads to the generation of a train of action potentials propagating along the axon. We find that for a narrow range of high current stimuli, the stimulus leads to different patterns of response. These patterns include series of spikes followed by a single failure and a single spike followed by some failures. For specific current stimulus regimes, chaotic behavior is observed. Figure 1. represents the three responses along the axon for different radii of axon. A constant current stimulus of 1.025 mA/cm² injected to a 20µm axon radius results in the generation of five action potentials followed by a single failure (A). Current stimulus of 8.5 mA/cm² injected to a 500µm axon radius results in generation of a single action potential followed by three failures (B). Current stimulus of 4.064 mA/cm² injected to a 238µm axon radius leads to a chaotic response (C). Interestingly, similar behaviors can be generated along axonal trees at the branching points. A train of action potentials that propagates in the main branch bifurcates into daughter branches. Some of the spikes may fail to pass the junction point, leading to electrical response pattern of failures between spikes. This response pattern depends on the radii ratio between the branches of the mother and the daughters. Meaning, the geometry of the junction affects the electrical activity of the daughter axon. These results highly depend on the temperature.