- Poster presentation
- Open Access
A computational model of striatal neural microcircuit: how dopamine release becomes important to the striatal functions
© Denizdurduran and Sengor; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Spike Train
- Dopamine Release
- Neuron Model
- Subcortical Region
The striatum is the main input structure of the basal ganglia circuits and the functions of this subcortical region are modified with dopaminergic innervation released from Substantia Nigra pars Compacta . We have focused on the formation of this subcortical region and its relation to the dopamine neurotransmitter since striatum has a key role in the basal ganglia functions, such as action selection and reward-based learning. The aim of this study is to find a plausible way to explain the effect of dopamine release on the functions and formations of striatal microcircuits. This work also focuses on the pathological synchrony within D2 MSN network which causes the repetitive projections of the Globus Pallidus External and Subthalamic Nucleus network . This pathological synchrony would be related to parkinsonian behavior as this network is primarily responsible for motor behaviors . It is now claimed that structure of the striatum is modified with long term depression (LTD) and long term potentiation (LTP) and dopamine regulates this structure . So, besides examining D2 network, we also have focused on D1 network to be able to explain how increased level of dopamine release causes the new formation within this region. In this work, we are following the Fast-Slow dynamical system approach to be able to model the Medium Spiny neurons. The striatal network comprises of 400 D1 MSNs, 400 D2 MSNs modeled as a conductance-based compartmental neuron model with 20 Fast-spiking inhibitory (FSIN) Adaptive and Exponential neuron models (%2) which matches the experimental observations .
This work is supported by TUBITAK Project no: 111E264.
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