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Assessing the role of synchronization and phase coherence in neural communication comparing cortical recordings and integrate-and-fire network models
BMC Neuroscience volume 14, Article number: P306 (2013)
Cognitive functions likely require that the routes of neural communication can be flexibly modulated. A proposed mechanism for modulating the effective strength of the connections in the neural dynamics relies on band specific neural synchronization and phase relations . Evidence of the modulation of neuronal interactions through the phase relation of rhythmic activity in the gamma band was provided in . Further evidence based on the analysis of a network of integrate-and fire neurons  has shown that the phase relation also modulates information transfer and is not specific of the gamma band. Here we combine the study of experimental recordings of local field potentials (LFP's) and multiple-unit activity (MUA) together with model data to better understand the origins of the phase-dependent modulation of interactions. Recordings include spontaneous activity and natural stimulus-driven activity in the monkey visual cortex V1 , as well as natural-stimulus driven activity in monkey auditory cortex . Simulations were obtained extending the recurrent network of integrate-and-fire neurons used in  to model the connectivity between two different brain areas.
We address some open questions regarding the generation, generality, and mechanistic nature of the phase-dependent modulation. We obtained, for any frequency band, the instantaneous power in each area (reflecting the local neural synchronization), and the instantaneous phases. We analyzed how the power correlation is modulated by the phase relation with a 1ms resolution, in contrast to the hundreds of milliseconds in . We found that this modulation is accompanied by changes in the magnitude of the power of each area separately. Accordingly, we evaluated the role of the power determining the degree of phase coherence and thus the existence of a preferred phase relation. We found that the optimal phase relation associated with maximal power correlation always corresponds to the preferred phase relation for large powers. These results are not frequency band specific and were reproduced with model data, using both unidirectional and bidirectional connections, as well as both excitatory-excitatory and excitatory-inhibitory connections. Our analysis suggests that the degree of local neural synchronization that determines the power of a given rhythm in each of the interacting areas plays a role to be considered together with the one of the phase relations as part of the mechanisms that modulate dynamically the effective strength of the connections.
Fries P: A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci. 2005, 9: 474-480. 10.1016/j.tics.2005.08.011.
Womelsdorf T, Schoffelen JM, Oostenveld R, Singer W, Desimone R, Engel AK, Fries P: Modulation of neuronal interactions through neuronal synchronization. Science. 2007, 316: 1609-1612. 10.1126/science.1139597.
Buehlmann A, Deco G: Optimal information transfer in the cortex through synchronization. PLoS Comput Biol. 2010, 6 (9): e1000934-10.1371/journal.pcbi.1000934.
Belitski A, Gretton A, Magri C, Murayama Y, Montemurro MA, Logothetis NK, Panzeri S: Low-frequency local field potentials and spikes in primary visual cortex convey independent visual information. J Neurosci. 28: 5696-5709.
Kayser C, Montemurro MA, Logothetis NK, Panzeri S: Spike-phase coding boosts and stabilizes the information carried by spatial and temporal spike patterns. Neuron. 2009, 61: 597-608. 10.1016/j.neuron.2009.01.008.
Mazzoni A, Panzeri S, Logothetis NK, Brunel N: Encoding of naturalistic stimuli by local field potential spectra in networks of excitatory and inhibitory neurons. PLoS Comput Biol. 2008, 4: e1000239-10.1371/journal.pcbi.1000239.
This work was supported by the SI-CODE FET-Open FP7-284533 project within the Seventh Framework for Research of the European Commission.
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Chicharro, D., Kayser, C. & Panzeri, S. Assessing the role of synchronization and phase coherence in neural communication comparing cortical recordings and integrate-and-fire network models. BMC Neurosci 14, P306 (2013). https://doi.org/10.1186/1471-2202-14-S1-P306
- Phase Relation
- Auditory Cortex
- Local Field Potential
- Phase Coherence
- Gamma Band