- Poster presentation
- Open Access
How adaptation currents and synaptic inhibition change threshold, gain and variability of neuronal spiking
© Ladenbauer et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Adaptation Current
- Synaptic Input
- Spike Rate
- Synaptic Inhibition
- Slow Potassium
Many types of neurons show spike rate adaptation, a gradual decrease in spiking activity following a sudden increase in stimulus intensity. This behavior is typically mediated by slow potassium currents through voltage-sensitive low-threshold or calcium-activated high-threshold channels, both of which are susceptible to cholinergic modulation . Such adaptation currents (and changes thereof) contribute to frequency selectivity , coding  and attention . These effects are likely caused by altering the relationship between synaptic input and spike rate output (I-O curve) as well as the characteristics of inter-spike intervals (ISI). Here we investigate (i) how voltage-dependent subthreshold and spike-dependent adaptation currents change the neuronal I-O curve as well as the ISI distribution for different input statistics and (ii) how these changes compare to those induced by synaptic inhibition.
Based on a population of adaptive exponential integrate-and-fire (aEIF) model neurons receiving noisy external and recurrent synaptic inputs we use the Fokker-Planck equation to compute spike rates and ISI distributions in the limit of a large adaptation timescale.
This work was supported by the DFG Collaborative Research Center SFB910.
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