- Poster presentation
- Open Access
Modeling spatio-temporal effects of propofol using a neural field approach
© Trong et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Local Circuit
- Left Temporal Lobe
- Neural Field
- Neurovascular Coupling
- Local Connection
Anesthetic agents like propofol induce global changes of brain states and behavior . Yet the relation to the observed spatio-temporal patterns of EEG and fMRI has not been fully understood. In this study, we use a biologically inspired neural field model to explain these patterns in the human brain induced by propofol.
where Θ is the differential operator accounting for the synaptic-dendritic dynamics, V is the vector of membrane potentials, S is a sigmoid function, t(d) is the time delay due to distal connections, H, T are the synaptic gains and characteristic time constants and I is the external input. With an appropriate neurovascular coupling and Balloon-Windkessel hemodynamic, the simulated ECoG (25 minutes) can be converted into changes of fMRI BOLD.
Our realistic model of the whole brain provides a powerful computational tool for investigating the spatio-temporal EEG and fMRI BOLD patterns during the application of propofol. Preliminary results match well both spatial and temporal characteristics of the experimental data.
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