- Poster presentation
- Open Access
Inferred Ising model unveils potentiation of pairwise neural interactions and replay of rule-learning related neural activity
© Ferrari et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Neural Activity
- Ising Model
- Rule Learning
- Slow Wave Sleep
- Recorded Activity
In a recent experiment  the prefrontal cortex activity of rats was measured using multi-electtrode recordings during the awake epoch and during the previous and subsequent slow wave sleep (SWS) periods. During the awake epoch the animal faces a task, such as following a light in a Y-shaped maze, where rule learning is rewarded with food. Through the analysis of the recorded activity by means of Principal Component Analysis, the replay of the activity during the SWS after the task was shown to occur. Here we re-analyze those data with an Ising model inference algorithm (the Selective Cluster Expansion, introduced in ) and we show how valuable informations can be extracted from the inferred parameters in the context of neural activity replay and neuroplasticity.
We start by binning, with a fixed bin-width of 10 ms, the recording of spiking times and by computing the set of probabilities that a single neuron is active in a single time-bin and the probabilities that a couple of neurons are active together in the same time-bin. We compute the value of the parameters of the Ising model (local fields and pairwise couplings), which allow us to reproduce those probabilities .
This work is founded by the FP7 FET OPEN project Enlightenment 284801.
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