- Poster presentation
- Open Access
Investigating dynamical properties of the Caenorhabditis elegans connectome through full-network simulations
© Kunert et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Neuron Model
- Input Stimulus
- Static Connectivity
- Nematode Caenorhabditis Elegans
- Neural Dynamic
The neuronal network of the nematode Caenorhabditis elegans (C. elegans) is comprised of 302 sensory, motor and inter-neurons. Near-complete connectivity data for the gap junctions and chemical synapses connecting these neurons (its connectome) have been resolved . In addition, current experiments measure the response of various neurons to input stimuli. A description of these responses cannot be drawn from the static connectivity data alone. These studies suggest that computational modeling can assist in describing neural dynamics and their relation to the connectome. However, simulations of C. elegans neural dynamics are challenging since the single neuron dynamics do not appear to be characterized by standard spiking neuron models. Indeed, genomic sequencing and electro - physiological studies have consistently failed to observe classical Na+ action potentials in C. elegans neurons .
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