Volume 14 Supplement 1
Behavioral effects of disrupted direct pathway signal flow caused by dopamine depletion
© Summerson et al; licensee BioMed Central Ltd. 2013
Published: 8 July 2013
The basal ganglia (BG) are involved in many functions, including voluntary motor control and cognition, and are the primary nuclei affected by Parkinson's disease (PD). A dominant pathological characteristic of PD is the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). Several symptoms of PD, such as increased delays in movement onset and reduced motor ability, can be directly related to the impaired flow of signals through the direct pathway, caused by dopamine depletion in the SNc . This altered computation of neural signaling in the BG affects both motor and associative circuits.
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