- Poster presentation
- Open Access
On the spatiotemporal dynamics and couplings across epileptogenic networks
© Proix and Jirsa; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Time Series
- Animal Model
- Brain Region
- Network Model
- Deep Insight
For patients with partial epilepsy, one or several brain regions generate seizures ('epileptogenic zone' ), which may recruit other regions that are themselves non-epileptogenic. For these patients, the epileptogenic zone can sometimes be surgically removed and thus must be precisely delineated using intracranial EEG, giving us a deeper insight into the spatiotemporal dynamic of the seizure.
Intracranial EEG times series show that brain regions and seizures may display a large variability in dynamics: (i) some seizures recruit more brain regions than others, (ii) the delays between the onset of the seizure in the epileptogenic zone and other areas can change on a time scale of several seconds, (iii) recruited areas exhibit different levels of coherence with the epileptogenic zone according to their position.
This research has been supported by the James S. McDonnell Foundation.
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