- Poster presentation
- Open Access
Full-scale structural model of the Inferior Olive and Olivocerebellar projection constructed from constraining meshes and directed growth
© Kozloski and Gurev; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Purkinje Cell
- Dendritic Arbor
- Dendritic Morphology
- Physiological Model
- Spike Generation
Constructing a full scale model of a brain structure demands several considerations. First, to be useful, the model must be of a computable size. Previously, we mapped the computation of dense multicompartmental models of neural tissue to the Blue Gene/P supercomputer at ~250 neurons per node of this machine. A ~30k neuron structure such as the Inferior Olive  is therefore well within the limits of today's machines, and so we aimed to build a structural model of this structure that could appropriately constrain a hypothetical physiological model.
Finally, we constrained dendritic morphology using a version of our previous model of self-referentially biased dendritic growth , modified to give a better match to olivary neuron morphology. This new model takes as input a 3-D mesh, which approximates nucleus boundaries using measurements of the Inferior Olive size and composition . As before, we generated dendritic arbors to match morphological measures , but determined that their characteristic spiral shape depends on a repulsive force from the bounding mesh. The full 24,815 dendritic arbors were then generated on 64 nodes of Blue Gene/Q, running 8 tasks/node, and 8 threads/task in <15 mins. (Figure 1C). We discuss future physiological models, including gap junctions, constrained by this structural model.
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