Visually guided behavior in freely moving mice
© Sriram et al; licensee BioMed Central Ltd. 2013
Published: 8 July 2013
The ability of neuroscience to ascribe functions to brain regions and to different neuronal subtypes within these regions depends on our ability to identify behavioral paradigms that depend on these functions and to measure these behaviors in a quantitative fashion. Due to their inexpensive nature, extensive similarities in brain architecture, availability of genetic tools and ease of handling, rodents have recently become an important tool in the study of neuronal coding. We train common mice (Mus musculus) in a potentially cortex dependent, visually guided task.
Past this initial training stage, subjects were tested on a variety of stimuli where the discriminated gratings showed varying spatial frequency (Figure 1B), contrast (Figure 1C), temporal frequency (Figure 1D) and orientation (Figure 1E) from the vertical allowing us to measure precise psychometric curves on the performance of subjects.
The role of cortical (Primary visual cortex; V1) and subcortical circuits (Superior colliculus; SC) mediating this behavior will be probed through the use of lesions. We hope that such measurements will provide a basis to constrain and in the future uniquely describe models of the neocortex.
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