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Computational modelling of micro-seizures and focal seizure onset
BMC Neuroscience volume 14, Article number: P14 (2013)
Pathological micro-domains have been proposed to underpin the generation of local pathological activity, as seen in focal seizures in the epileptic cortex [1–3]. Specifically, so-called micro-seizures have been suggested to be markers for these micro-domains [2, 3]. Astonishingly, micro-seizures have also been observed in non-epileptic control patients . This suggests that local activity, such as micro-seizures, only become pathological when in a specific arrangement.
We hypothesize that pathological dynamics could be due to an increased density of micro-domains. To test this, we introduce a computational model on the mesoscopic scale of a 5 × 5 mm2 cortical sheet . The units are modelled as excitable minicolumns. This model also incorporates realistic connectivity schemes observed at this spatial scale .
The model shows occasional, non-pathological micro-seizure occurrences, as well as recruitment of normal tissue into full-blown seizure activity in the presence of dense clusters of hyperactive micro-seizure domains. A specific prediction of this model is that the transition to full-blown seizures can be prevented by using micro-incisions to separate the clusters of abnormally active micro-domains (Figure. 1) .
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Wang, Y., Taylor, P.N. & Baier, G. Computational modelling of micro-seizures and focal seizure onset. BMC Neurosci 14, P14 (2013). https://doi.org/10.1186/1471-2202-14-S1-P14
- Spatial Scale
- Computational Model
- Control Patient
- Local Activity
- Seizure Activity