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  • Open Access

Computational modelling of micro-seizures and focal seizure onset

BMC Neuroscience201314 (Suppl 1) :P14

https://doi.org/10.1186/1471-2202-14-S1-P14

  • Published:

Keywords

  • Spatial Scale
  • Computational Model
  • Control Patient
  • Local Activity
  • Seizure Activity

Pathological micro-domains have been proposed to underpin the generation of local pathological activity, as seen in focal seizures in the epileptic cortex [13]. Specifically, so-called micro-seizures have been suggested to be markers for these micro-domains [2, 3]. Astonishingly, micro-seizures have also been observed in non-epileptic control patients [3]. This suggests that local activity, such as micro-seizures, only become pathological when in a specific arrangement.

We hypothesize that pathological dynamics could be due to an increased density of micro-domains. To test this, we introduce a computational model on the mesoscopic scale of a 5 × 5 mm2 cortical sheet [4]. The units are modelled as excitable minicolumns. This model also incorporates realistic connectivity schemes observed at this spatial scale [5].

The model shows occasional, non-pathological micro-seizure occurrences, as well as recruitment of normal tissue into full-blown seizure activity in the presence of dense clusters of hyperactive micro-seizure domains. A specific prediction of this model is that the transition to full-blown seizures can be prevented by using micro-incisions to separate the clusters of abnormally active micro-domains (Figure. 1) [6].
Figure 1
Figure 1

First column indicated the location of the pathological clusters in black and the position of the micro-incision using the labeled line. The second column shows the temporal average activity in 10000 simulation steps. The third column indicates the spatial average of the same simulation using the black line and the purple lines show the spatial average of 10 × 10 subsquares, which represent macro-columns in the model. (A) Resulting simulation after a 5 minicolumn long micro-incision. (B) Resulting simulation after a 10 minicolumn long micro-incision. (C) Resulting simulation after a 45 minicolumn long micro-incision.

Authors’ Affiliations

(1)
Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK
(2)
School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore
(3)
Division of Bioscience, Faculty of Life Sciences, University College London, London, WC1E 6BT, UK

References

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  3. Stead M, Bower M, Brinkmann BH, Lee K, Marsh WR, Meyer FB, Litt B, Van Gompel J, Worrell GA: Microseizures and the spatiotemporal scales of human partial epilepsy. Brain. 2010, 133: 2789-2797. 10.1093/brain/awq190.PubMed CentralView ArticlePubMedGoogle Scholar
  4. Wang Y, Goodfellow M, Taylor PN, Gary DJ, Baier G: Computational Modelling of Microseizures and Focal Seizure Onset. Proceedings of IWSP5. Edited by: K. Lehnertz, R. Tetzlaff, C. Elger. 2013, World ScientificGoogle Scholar
  5. Voges N, Schüz A, Aertsen A, Rotter S: A modeler's view on the spatial structure of intrinsic horizontal connectivity in the neocortex. Prog Neurobiol. 2010, 92: 277-292. 10.1016/j.pneurobio.2010.05.001.View ArticlePubMedGoogle Scholar
  6. Wang Y, Goodfellow M, Taylor P, Garry D, Baier G: Computational modelling of microseizures and focal seizure onset. International Seizure prediction workshop proceedings. Dresden 2011 (to appear)Google Scholar

Copyright

© Wang et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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