Skip to main content


We're creating a new version of this page. See preview

  • Poster presentation
  • Open Access

Abatement of epileptic spike-wave discharges through single pulse stimulation

  • 1,
  • 2,
  • 1 and
  • 3
Contributed equally
BMC Neuroscience201314 (Suppl 1) :P13

  • Published:


  • Single Pulse
  • Epileptic Patient
  • Absence Seizure
  • Auditory Stimulation
  • Pulse Stimulation

Spike-wave discharges (SWD) are a striking phenomena detectable on the electroencephalogram (EEG) of all patients during absence seizures. There is experimental and clinical evidence to suggest that seizures can be terminated early through the use of short auditory stimulation [1], however, stimulation protocols for seizure abatement are underdeveloped and their varied success is poorly understood.

In this work we extend the model of [2] to account for known thalamocortical connectivity which has previously been implicated in SWD [3]. This model is capable of producing transient spike-wave trains upon perturbation, for example, through the inclusion of noise. We show that a single pulse perturbation during a simulated seizure can, if applied with the correct timing and amplitude, successfully terminate the seizure early (Figure. 1a). Furthermore, if the same stimulus is applied incorrectly (e.g. at a different time) the seizure could be prolonged (Figure. 1b). The complex phase and amplitude dependency of successful stimulation can be explained in the model with its nontrivial phase space configuration. The complex and sensitive dependency could account for the variations in success of different clinical and experimental stimulation studies. Our modeling approach makes the prediction that these optimal stimuli can be predicted through the use of a learning algorithm included in a closed-loop stimulation device as suggested by [1]. Successful clinical implementation and application of such a learning algorithm could have dramatic impact on epileptic patients and offer a potential alternative to anti-epileptic drug based therapy. The combination of animal experiments on seizure control of SWD [4, 5] and the current model predictions regarding strength and timing could lead to improved translation into the clinical setting.
Figure 1
Figure 1

(A) Successful single pulse stimulation applied at 0.15 seconds after seizure onset. Blue dashed line indicates the SWD duration without a stimulus. (B) Unsuccessful single pulsestimulation applied 0.2 seconds after seizure onset.


Authors’ Affiliations

School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore
Manchester Interdisciplinary Biocentre, University of Manchester, UK
Centre for Organismal Studies, University of Heidelberg, Germany


  1. Rajna P, Lona C: Sensory stimulation for inhibition of epileptic seizures. Epilepsia. 1989, 30 (2): 168-174. 10.1111/j.1528-1157.1989.tb05450.x.View ArticlePubMedGoogle Scholar
  2. Taylor PN, Baier G: A spatially extended model for macroscopic spike-wave discharges. J Comput. Neurosci. 2011, 31 (3): 679-684. 10.1007/s10827-011-0332-1.View ArticlePubMedGoogle Scholar
  3. Pinault D, O'Brien T: Cellular and network mechanisms of genetically-determined absence seizures. Thalamus Relat Syst. 2005, 3 (3): 181-10.1017/S1472928807000209.PubMed CentralView ArticlePubMedGoogle Scholar
  4. Saillet S, Gharbi S, Charvet G, Deransart C, Guillemaud R, Depaulis A, David O: Neural adaptation to responsive stimulation: A comparison of auditory and deep brain stimulation in a rat model of absence epilepsy. Brain Stimul. 2012Google Scholar
  5. Berényi A, Belluscio M, Mao D, Buzsáki G: Closed-loop control of epilepsy by transcranial electrical stimulation. Science. 2012, 337 (6095): 735-737. 10.1126/science.1223154.View ArticlePubMedGoogle Scholar


© Taylor et al; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.