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Interlaminar processing in auditory cortex before and after auditory trauma: spontaneous and evoked responses of independent sources

The interaction of neural populations within the neocortex is mainly characterized by which layer they located in. For instance: thalamocortical input projects to layer 4 cells, which in turn project to layer 2/3 cell. Layer 2/3 cells then forward signals onto layer 5 cells [4]. However, it is difficult to see interactions within layers, or even which neural populations in one layer may be interacting with other layers. Very fast oscillations (VFOs, $>$80 Hz) have been associated with neocortical processing [1, 3], and have distinct roles in different cortical layers [3]. Moreover, VFOs increase in temporal lobe epilepsy [2, 6], which is associated with trauma [5]. In this study, we take a more detailed look at interlaminar interactions, VFOs, and the effects of trauma by applying independent component analysis (ICA) to recordings from rat auditory cortex.

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Correspondence to Erin Munro.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Animal Model
  • Temporal Lobe
  • Independent Component Analysis
  • Independent Component
  • Temporal Lobe Epilepsy