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Interlaminar processing in auditory cortex before and after auditory trauma: spontaneous and evoked responses of independent sources

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The interaction of neural populations within the neocortex is mainly characterized by which layer they located in. For instance: thalamocortical input projects to layer 4 cells, which in turn project to layer 2/3 cell. Layer 2/3 cells then forward signals onto layer 5 cells [4]. However, it is difficult to see interactions within layers, or even which neural populations in one layer may be interacting with other layers. Very fast oscillations (VFOs, $>$80 Hz) have been associated with neocortical processing [1, 3], and have distinct roles in different cortical layers [3]. Moreover, VFOs increase in temporal lobe epilepsy [2, 6], which is associated with trauma [5]. In this study, we take a more detailed look at interlaminar interactions, VFOs, and the effects of trauma by applying independent component analysis (ICA) to recordings from rat auditory cortex.


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Correspondence to Erin Munro.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Munro, E., Sakata, S. & Toyoizumi, T. Interlaminar processing in auditory cortex before and after auditory trauma: spontaneous and evoked responses of independent sources. BMC Neurosci 14, P125 (2013) doi:10.1186/1471-2202-14-S1-P125

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  • Animal Model
  • Temporal Lobe
  • Independent Component Analysis
  • Independent Component
  • Temporal Lobe Epilepsy