- Poster presentation
- Open Access
Spike timing in rat somatosensory cortex contributes to behavior
- Alberto Mazzoni†1Email author,
- Zuo Yanfang†2,
- Giuseppe Notaro3,
- Stefano Panzeri†1, 4 and
- Mathew E Diamond†2
https://doi.org/10.1186/1471-2202-14-S1-P109
© Mazzoni et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
Keywords
- Spike Train
- Somatosensory Cortex
- Spike Timing
- Error Trial
- Spike Count
The precise spike timing of sensory neurons carries more information about stimuli than the number of spikes counted over longer time windows [1–3]. However, the behavioral relevance of this extra information remains to be assessed. To investigate whether precise timing contributes to behavior, we considered spike trains recorded extracellularly in the rat somatosensory cortex during a texture discrimination task [4, 5].
We analyzed the spike trains following the contact of the whiskers with the texture and we measured the information carried about texture by post-touch spike times and spike counts. This analysis is technical challenging because it is difficult to quantify the information content of precise patterns of spike that extend over relatively long time windows with the relatively little number of trials available in behavioral experiments. To address this challenge, we reduced the dimensionality of the response space by decomposing single trial spike train densities into Principal Components (PCs), selecting the most informative PC as the "temporal template" to interpret neural responses, and finally measuring the information about the presented texture carried by the projection of each trial relative to this template. We compared the so -measured spike timing information with the information carried by spike counts and we found that spike times carried more than 60% more texture information than spike counts.
Next, we reasoned that if a neuronal coding mechanism contributes to behavior, then the code would be found to transmit less stimulus information in error trials, i.e. trials in which the rat made the wrong choice. We found that the texture information carried both by spike counts and spike patterns decreased significantly when we included error trials in the analysis, but the effect was much more pronounced for patterns (30% information decrease) than for counts (~15% information decrease). These differences between spike pattern and spike count codes hold for both primary and secondary somatosensory cortex, suggesting that spike timing could contribute to behavior at different stages of the sensory processing.
Taken together, these results indicate that in the somatosensory cortex the time at which spikes occur, not just the number of spikes, makes a crucial contribution to tactile perception.
Notes
Declarations
Acknowledgements
This work was supported by the SI-CODE FET-Open FP7-284533 project within the Seventh Framework for Research of the European Commission
Authors’ Affiliations
References
- Panzeri S, Brunel N, Logothetis NK, Kayser C: Sensory neural codes using multiplexed temporal scales. Trends in Neurosci. 2009, 33: 111-121.View ArticleGoogle Scholar
- Victor JD: How the brain uses time to represent and process visual information. Brain Res. 2000, 886: 33-46. 10.1016/S0006-8993(00)02751-7.View ArticlePubMedGoogle Scholar
- Panzeri S, Petersen RS, Schultz SR, Lebedev M, Diamond ME: The role of spike timing in the coding of stimulus location in rat somatosensory cortex. Neuron. 2001, 29: 769-777. 10.1016/S0896-6273(01)00251-3.View ArticlePubMedGoogle Scholar
- Diamond ME, von Heimendahl M, Knutsen PM, Kleinfeld D, Ahissar E: 'Where' and 'what' in the whisker sensorimotor system. Nat Rev Neurosci. 2008, 9: 601-613. 10.1038/nrn2411.View ArticlePubMedGoogle Scholar
- von Heimendahl M, Itskov PM, Arabzadeh E, Diamond ME: Neuronal activity in rat barrel cortex underlying texture discrimination. PLoS Biol. 2009, 5: e305-doi:10.1371/journal.pbio.0050305View ArticleGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
