- Poster presentation
- Open Access
Reduction in inhibitory control is sufficient to generate hyperalgesia in a spiking model of nociceptive integration in the superficial dorsal horn
© Sousa et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Receptive Field
- Dorsal Horn
- Inhibitory Control
- Projection Neuron
- Inhibitory Interneuron
The spinal cord's dorsal horn is a major termination site for primary afferents carrying sensory information from the periphery. The superficial dorsal horn (SDH, laminae I and II), in particular, receives inputs from nociceptive C and Aδ fibers, and have an important role in relaying and processing nociceptive information. This work focuses on the pain condition named hyperalgesia, characterized by an increased response to a stimulus that is normally painful. Much is still unknown regarding the central mechanisms giving rise to this condition.
This model shows that mechanisms interfering with the balance between excitation/inhibition and reducing, temporarily or chronically, the feed-forward inhibitory control in the SDH have the potential to give rise to hyperalgesia. Understanding how this pain condition occurs provides important information on how to reverse pathological situations. This work was supported by grant SFRH/BD/60690/2009 from FCT.
- Takahashi Y, Chiba T, Kurokawa M, Aoki Y: Dermatomes and the Central Organization of Dermatomes and Body Surface Regions in the Spinal Cord Dorsal Horn in Rats. J Comp Neurol. 2003, 462 (1): 29-41. 10.1002/cne.10669.View ArticlePubMedGoogle Scholar
- Sandkühler J: Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009, 89 (2): 707-758. 10.1152/physrev.00025.2008.View ArticlePubMedGoogle Scholar
- Pinto V, Szucs P, Lima D, Safronov B: Multisegmental Aδ- and C-Fiber Input to Neurons in Lamina I and the Lateral Spinal Nucleus. J Neurosci. 2010, 30 (6): 2384-2395. 10.1523/JNEUROSCI.3445-09.2010.View ArticlePubMedGoogle Scholar
- Yasaka T, Tiong S, Hughes D, Riddell J, Todd AJ: Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. Pain. 2010, 475-488. 151Google Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.