- Oral presentation
- Open Access
Multiscale modeling of cortical information flow in Parkinson's disease
© Kerr et al; licensee BioMed Central Ltd. 2013
- Published: 8 July 2013
- Firing Rate
- Field Model
- Granger Causality
- Subthalamic Nucleus
- Neural Field
The basal ganglia play a crucial role in the execution of movements, as demonstrated by the severe motor deficits that accompany the neuronal degeneration underlying Parkinson's disease (PD). Since motor commands originate from the cortex, an important functional question is how the basal ganglia influence cortical information flow, and how this influence becomes pathological in PD. In contrast, previous models of PD have focused on either global brain dynamics or on local information flow, since developing a model that is valid on both scales presents a major technical challenge.
To address this issue, we developed a composite neuronal network/neural field model. The neuronal network consisted of 4950 event-driven rule-based neurons, divided into 15 excitatory and inhibitory cell populations in the thalamus and cortex. This model was then embedded in a neural field model of the basal ganglia-thalamocortical system, including the cortex, thalamus, striatum, subthalamic nucleus, and globus pallidus. Both network and field models have been separately validated in previous work [1–3], with both shown to produce realistic firing rates and spectra. Two field models were explored: one with parameters based on data from healthy individuals, and one based on data from individuals with PD. Spikes generated by these field models (which represent inputs from distant brain areas) were then used to drive the network model (which represents a small region of association cortex). We then explored the effects that these drives had on the information flow and dynamics of the network.
- Kerr CC, Neymotin SA, Chadderdon GL, Fietkiewicz CT, Francis JT, Lytton WW: Electrostimulation as a prosthesis for repair of information flow in a computer model of neocortex. IEEE Trans Neural Syst Rehabil Eng. 2012, 20: 153-160.View ArticlePubMedGoogle Scholar
- Van Albada SJ, Robinson PA: Mean-field modeling of the basal ganglia-thalamocortical system. I. Firing rates in healthy and parkinsonian states. J Theor Biol. 2009, 257: 642-63. 10.1016/j.jtbi.2008.12.018.View ArticlePubMedGoogle Scholar
- Van Albada SJ, Gray RT, Drysdale PM, Robinson PA: Mean-field modeling of the basal ganglia-thalamocortical system. II. Dynamics of parkinsonian oscillations. J Theor Biol. 2009, 257: 664-88. 10.1016/j.jtbi.2008.12.013.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.